Saskia and Jenny - twins - are alike in appearance only. Saskia is a grad student with a single-minded focus on her studies, while Jenny is glamorous, thrill-seeking, and capricious. Still, when Jenny is severely injured in an accident, Saskia puts her life on hold to be with her sister. Sara and Mattie are sisters with another difficult dynamic. Mattie, who is younger, is intellectually disabled. Sara loves nothing more than fine wines, perfumes, and expensive clothing, and leaves home at the first opportunity. But when their mother dies, Sara inherits the duty of caring for her sister. Arriving at the house one day, she is horrified to discover that Mattie has married their mother's handyman. The relationship ends in tragedy. Now, Sara and Saskia, both caregivers for so long, are on their own - and come together through a cascade of circumstances as devastating as they are unexpected.