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Eve Laing, once the muse of an infamous painter, is now - forty years later - an artist herself. But she feels she has sacrificed her career for her family and she resents the global success of her old college roommate, now a celebrity of the international conceptual art scene. When Eve embarks on her most ambitious work yet, she takes a wrecking ball to her comfortable life, jettisoning her marriage for a beautiful young lover, a drifter half her age, who seems to share her single-minded creative vision. 'Nightshade' charts Eve's nocturnal walk through London, from her former family home in the west of the city back to her studio, a converted factory in the east, where her recently completed masterpiece hangs and a fatal reckoning awaits.